Inter Milan have sacked manager Frank de Boer after just 85 days in charge of the Italian club.
Inter are 12th in the Serie A table after a 1-0 loss at Sampdoria on Sunday, their fourth defeat in five league games.
Former Netherlands defender and ex-Ajax boss De Boer, 46, was heavily linked with vacancies at Premier League clubs Everton and Southampton in the summer.
Inter visit Southampton in the Europa League on Thursday (20:05 GMT).
Youth team coach Stefano Vecchi will take charge of the first team for that fixture.
De Boer led Ajax to four successive Dutch titles but lost out to PSV Eindhoven on the final day of last season.
He signed a three-year contract with Inter in August, replacing former Manchester City manager Roberto Mancini.
It is six years since Inter won the treble of Serie A, Coppa Italia and Champions League under Jose Mourinho, now Manchester United boss, but since coming second in 2011 they have finished sixth, ninth, fifth, eighth and fourth.
They are now looking for a ninth manager since Mourinho left in the summer of 2010.
Newcastle boss Rafael Benitez, Leicester manager Claudio Ranieri and Watford boss Walter Mazzarri have all coached at the San Siro in the past six years.